Investigation of the effect of vascular endothelial growth factor gene 936 C/T polymorphism in familial Mediterranean fever patients

Objectives: This study aims to investigate the effect of vascular endothelial growth factor (VEGF) gene 936C/T polymorphism (rs3025039) on appearance phenotypic characteristics familial Mediterranean fever (FMF) patients that differ with respect MEditerranean FeVer (MEFV) mutations. Here, we investigated a single functional in VEGF gene. Methods: The group consisted 223 FMF definite diagnosis according Tel-Hashomer criteria who carried MEFV mutations, while 208 but without any making up control group, were included study. was genotyped using polymerase chain reaction-restriction fragment length (PCR-RFLP) technique. Results: Genotype and allele frequencies rs3025039 between two groups significantly different (p = 0.03 p 0.011, respectively). TT genotype found be more frequent than controls (4.9% vs. 3.3%, Conclusions: Our results seem indicate affects FMF. It is possible other variants this may also have similar effects.